DNA present within cells, collectively known as the genome, is the instruction manual read by the cellular machinery to live and function. My lab is interested in understanding how the variation in genomes of Indians predisposes them to disparities in health and disease. We study this at two levels. First, we identify genetic variation of individuals using cutting-edge high throughput sequencing technologies. As part of large nation-wide population genomics programs, we map the natural variation in healthy genomes. In particular, our interests lie in two classes of variations known as structural variations and tandem repeats. We also study how the same DNA sequence can give rise to different phenotypes, as observed in various cell types of a single organism. Despite having an identical genome, cells can be regulated differently via epigenetic mechanisms that result in cell specific gene expression patterns. Using single cell genomic technologies, we analyze the gene expression and epigenetic profiles of various cells to understand cell heterogeneity. Finally, we develop new computational methods that enable faster and better analysis of complex biological data, as well as more interactive and intuitive data visualization.